Symptoms of hemochromatosis

* "Symptoms of Hemochromatosis" by the American Hemochromatosis Society

Liver damage (cirrhosis/cancer)

* Percutaneous Liver Biopsy: A Safe Outpatient Procedure? (mar 2001)

* Noninvasive prediction of fibrosis/cirrosis

* Cirrhosis of the Liver

* PDF: Mild liver enzyme abnormalities: eliminating hemochromatosis as cause: 1997 Aug.

* Questions and Answers About Liver Cancer

* Adult primary liver cancer

* Cirrhosis of the Liver: MedicineNet

* Cancer of the Liver: general information from MedicineNet

* Liver transplantation in patients with hepatic iron overload: favorable or unfavorable outcome?: Hepatology 2000 Dec;32(6):1396-8

* Livercancer in a patient with hereditary hemochromatosis without cirrhosis

* Livercancer arising in non-cirrhotic liver in genetic haemochromatosis.

* Liver cancer occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases

Livercancer arising in the absence of cirrhosis in genetic haemochromatosis: three case reports and review of literature.

Cancer (other forms, for livercancer see above )

* Haemochromatosis and breast cancer: a rare cause of a rare disease?

* Increased cancer risk in a cohort of 230 patients with HH --> Reply to this article (full text)

Liver transplantation

* December 2000: Liver transplantation in patients with hepatic iron overload: Favorable or unfavorable outcome? xxx Article in PDF

* February 2000: Iron overload in cirrhosis—HFE genotypes and outcome after liver transplantation xxx Article in PDF

* September 1999: Prevalence of the C282Y Mutation of the Hemochromatosis Gene in Liver Transplant Recipients and Donors

* Increased hepatic iron and cirrhosis: No evidence for an adverse effect on patient outcome following liver transplantation.: Hep 2000 Dec;32(6):1200-7

* February 2000: Iron overload in cirrhosis—HFE genotypes and outcome after liver transplantation xxx

Liver general Links

* American Liver Foundation

* Merck on liver diseases

* Liver Diseases

* ABC of diseases of liver, pancreas, and biliary system Investigation of liver and biliary disease: BMJ, january 6 2001

Heart

* September 2000: Iron Overload and Atherosclerosis xxx Article in PDF

* Iron and the heasrt: Harvard

* September 2000: Radial artery wall alterations in genetic hemochromatosis before and after iron depletion therapy

* Hemochromatosis and Heart: MEDLINE

* Marlboros and iron don´t mix

* Iron and the Heart: pilot study in reduction of body iron

* Too much iron ups heart risk

* Blooddonation and Heart diseases; BMJ: 21 june 1997

* Donating blood reduces haert-risk: Reuters, 9 september 1998

* Review on heart disease and iron: Archives of Internal Medicine, 1999

* Cholesterol-Iron on still hot debate CNN (1995)

* Secondary and Infiltrative Cardiomyopathies.: Curr Treat Options Cardiovasc Med 2000 Oct;2(5):373-384

* Japanese Heart-Disease Study Focuses on Iron Role: 25 oktober 2000

* BBC: Iron 'rusts' up blood vessels (26 okt 2000)

* Iron and the Heart: pilot study in reduction of body iron (jan 2000)

* PDF: Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women: 1999 Sep

* PDF: Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation : a prospective cohort study in men in eastern Finland; 1999 Sep

* Search Circulation for iron

* Gene Studies links iron with cardiovascular disease riskLancet, 25 september 1999Article in PDF

*  Congestive Heart Failure: general information from MedicineNet

Porphyria Cutanea Tarda

* Omim: PCT Type II

* PCT in the HFE-Gene and Hepatitis C virus Era (december 2000)

* Blood: march 2000: Hemochromatosis genes and other factors contributing to PCT (PDF-file)

* BMJ: june 2000; Regular review: Diagnosis and management of porphyria

* PCT on dermnet!!!

* PCT by the Iron Disorders Institute

* PCT Photo's (extreme cases!!!)

* Porphyria web links

* American Porphyria Foundation

* Dec 1999: Extremely Rare Association of HFE Mutations With Porphyria Cutanea Tarda in Japanese Patients

* January 1997: The frequency of hemochromatosis-associated alleles is increased in British patients with sporadic porphyria cutanea tarda xxx Article in PDF

* January 1998: High Prevalence of the His63Asp HFE Mutation in Italian Patients With Porphyria Cutanea Tarda xxx Article in PDF

* January 1998: Mutations in the Hemochromatosis Gene, Porphyria Cutanea Tarda, and Iron Overload xxx

* Iron overlaod in PCT

Joints and Hemochromatosis

* Medline: osteoarthritis and hemochromatosis

* Osteoporosis: HH is named 2 or 3 times)

* Gout and Pseudogout

* Gout: Beyond the Stereotype

* Medline: Joints and hemochromatosis

* Medline: calcium pyrophosphate dihydrate and hemochomatosis

* Omim: Chondrocalcinosis

* Pseudogout: general information from MedicineNet

* Hemochromatosis: arthritis and pseudogout: Ask the Experts: Medicinenet

* Reumatology.org

* Chondrocalcinosis: Medical college of Wisconsin

* Pseudogout: University of washington

* (PDF!)Elevated parathyroid hormone 44-68 and osteoarticular changes in patients with genetic hemochromatosis

* American college of Reumatology: patients factsheets

* Magazine: arthritis and Reumatism --> search for hemochromatosis --> some articles

* Video from Kaiser about hemochromatosis and joints (AHS-site)

Diabetes

* Iron and Diabetes

* C282Y mutation and type 2 diabetes: BMJ: 18 november 2000

* Iron and Diabetes: BMJ: 12 september 1998

* Diabetes: general information from MedicineNET

Hepatitis

April 1999: Hemochromatosis C282Y Mutation and Histological Fibrosis in Patients With C Virus Chronic Hepatitis xxx Article in PDF

January 1998: Hemochromatosis Cys282Tyr Mutation and Liver Iron Overload in Patients With Chronic Active Hepatitis C xxx Article in PDF

* July 2000: Iron Reduction as an Adjuvant to Interferon Therapy in Patients With Chronic Hepatitis C Who Have Previously Not Responded to Interferon: A Multicenter, Prospective, Randomized, Controlled Trial xxx

* July 2000: Iron Reduction as an Adjuvant to Interferon Therapy in Patients With Chronic Hepatitis C Who Have Previously Not Responded to Interferon: A Multicenter, Prospective, Randomized, Controlled Trial xxx Article in PDF

* March 2000: Iron Reduction Before and During Interferon Therapy of Chronic Hepatitis C: Results of a Multicenter, Randomized, Controlled Trial xxx Article in PDF

* Iron overload in patients with chronic viral hepatitis: how common is it?

* A pilot randomized, controlled trial of the effect of iron depletionon long-term response to alpha-interferon in patients with chronic hepatitis C

* SIGNIFICANT CORRELATION BETWEEN LIVER IRON DEPOSITION AND HEPATOCELLULAR CARCINOMA IN PATIENTS WITH VIRAL C CIRRHOSIS. STUDY OF 104 PATIENTS

* HCV and C282Y (Gastroenterology 1999)

* Hepatitis C and Hemochromatosis: MedicineNet

* Iron reduction therapy and more

Chronic fatigue

* CFIDS (Chronic Fatigue Syndrome) and Hemochromatosis -->The article in Dutch

Infertility, impotence, etc.

* Impotence: general information from MedicineNet

* Male infertility overview

* Lancet 14 jan 2001; The pituitary gland and hereditary hemochromatosis (PDF!)

Hypogonadism

* Pseudogout: University of Washington

Fibromyalgia (see also the IBS section above)

Muscle cramps

* Medline: muscle and cramps

* Cirrosis and muscle cramp

* Randomised controlled trial of hydroquinine in muscle cramps.: Lancet 1997 Feb 22;349(9051):528-32

* Quinine-induced hepatotoxicity.; Ann Pharmacother 1999 Jan;33(1):32-4

* Muscle Cramps and Sport

* Cramps at On-Health Web MD

* Short text on muscle cramp from excess-iron list: Exact source unknown!

Restless legs syndrome

* Hemochromatosis and iron therapy of Restless Legs Syndrome.
* PubMed: Articles on: "Iron and the restless legs syndrome"
* Restless Legs syndrome
* Restless leg Foundation

Infections

* Effects of iron overload on the immune system. ;Ann Clin Lab Sci 2000 Oct;30(4):354-65

Hair loss

* Hair loss and hemochromatosis: a hair page

Brain / Neurologic Problems

* Headache and hemochromatosis: Medline

* Clinical report of three patients with hereditary hemochromatosis and movement disorders.: Mov Disord 2000 Nov;15(6):1204-9

* High iron may mean worsening stroke: Health Scout

* Jama: Stroke damage from iron

Parkinson/Alzheimer

* Is hemochromatosis a risk factor for hemochromatosis? (In Press, sept 2001)

* Iron Problems May Lead to Parkinson's: Health Scout (30 jan 2001)

* Iron in the brain of Parkinson disease sufferers

*Iron in the Brain: IOD

* Are heriditary hemochromatosis mutations involved in Alzheimer disease?

* Erratum: are hereditary hemochromatosis mutations involved in alzheimer disease?; Am J Med Genet 2000 Nov 13;95(2):189

* Clinical report of three patients with hereditary hemochromatosis and movement disorders.: Mov Disord 2000 Nov;15(6):1204-9

* Pumping iron in Parkinson´s disease: Lancet; 1996

Autism

* Hypothesis: Iron overload and autism

Bowel/Colon

* Hemochromatosis gene (HFE) mutations are associated with an increased risk of colon cancer.

* Colorectal cancer and HFE mutations (may, 1999)

* Iron and colorectal cancer risk: human studies (review, may 2001)

eyes

* Medline: Ocular and hemochromatosis

* (670Kb!!!) (1 page) Corneal Findings in Hemochromatosis: article

Skin

* Rashes and skin allergies

* Letter from excess-iron list on Red palms and itching

Lungs

* Many links on Pulmonary Hemosiderosis

* Smoking and hemochromatosis

* Heterozygotes and extra risk when smoking

* Iron and welding (Medline)

Kidneys

Epilepsy

Hearing-loss

Other symptoms related to iron (incomplete list!!!)

* Wilson disease and hemochromatosisLancetArticle in PDF

* Iron loading: a risk factor for Whipple's disease?